VIOXX AND CELEBREX INCREASE HEART ATTACKS?

Note: This report was written in March 2001. Vioxx was removed from the market in 2004, and Celebrex now has warnings. The Food and Drug Administration reports that two arthritis drugs called Celebrex and Vioxx, are associated with increased risk for heart attacks. That does not mean that these drugs cause heart attacks.

Aspirin and other drugs use to treat arthritis, block cox-1 prostaglandins that protect kidneys and stomach from damage and cox-2 prostaglandin that cause redness, swelling and pain. So a common side effect of most arthritis drugs is that they can cause stomach ulcers and kidney damage. However, the new cox-2 blockers, Celebrex and Vioxx, to stop pain and swelling and are less likely to cause stomach ulcers and kidney damage. But recent reports show that people who Take Vioxx and Celebrex are at higher risk for heart attacks than people who take aspirin and other arthritis medications. It's not because Vioxx and Celebrex cause heart attacks, it's because they do not prevent clotting that causes heart attacks.

FDA Committee report March, 2001

Checked 8/9/05

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