Myriad scientific papers show that heart attacks may be caused by infection with chlamydia and other bacteria and viruses. Most main-stream heart specialists feel that infection with chlamydia can cause heart attacks, but most doctors are afraid to prescribe new treatments.
Most people who develop fatty plaques in their arteries have been infected with chlamydia (25) and many people with arteriosclerotic heart disease carry chlamydia in their mouths (26). I recommend a short course of doxycycline or azithromycin to A) people and their sexual partners who have had heart attacks or strokes, or who are at high risk for heart attacks because of extensive arteriosclerosis and B) have a positive antibody blood test for chlamydia or mycoplasma. In one year, most physicians will do the same, but now most physicians disagree with me even though studies show that antibiotics prevent heart attacks (10,28).
Previous studies show that chlamydia is associated with (11,8) and has been found repeatedly in plaques that form in arteries to cause heart attacks (1,2,13,20), high blood pressure (15) and strokes (16). Antibodies combine with chlamydia to form immune complexes that convert the bad LDL cholesterol to oxidized cholesterol to form plaques in arteries (3,4,5). People with high blood levels of C-reactive protein, an indicator of infection, are the ones most likely to suffer heart attacks and strokes (19), and aspirin reduces inflammation (29) caused by infection in the inner lining of arteries and prevents heart attacks (6). People who have had heart attacks are more likely to die if they have high blood levels of C-reactive protein (12). Being infected with chlamydia is associated with increased risk for heart attacks (21,23,25,31) and having chlamydia increases a heart attack victim's chances of suffering another heart attack fourfold (7), presumably by increasing susceptibility to clotting (17). Treating with azithromycin, an antibiotics that kills chlamydia, prevents second heart attacks (7). An antibiotic that kills chlamydia helped relieve symptoms in people with angina chest pain (8). Herpes simplex and cytomegalovirus have also been associated with heart attacks (22). To prevent heart attacks, eat a low fat, high-fiber diet and treat chronic infections.
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2) JL Mehta, TGP Saldeen, K Rand. Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease. Journal of the American College of Cardiology 31: 6(MAY 1998):1217-1225.
3) T Watanabe, S Haraoka, T Shimokama. Inflammatory and immunological nature of atherosclerosis. International Journal of Cardiology 54: Suppl. (AUG 1996):S51-S60.
4) RH Fryer, EP Schwobe, ML Woods, GM Rodgers. Chlamydia species infect human vascular endothelial cells and induce procoagulant activity. Journal of Investigative Medicine 45: 4 (APR 1997):168-174.
5) RW Wissler, AL Roberts, JP Strong, JF Cornhill, and more than 55 others. Atheroarteritis: A combined immunological and lipid imbalance. International Journal of Cardiology 54: Suppl.(AUG 1996):S37-S49. Address: RW Wissler, Univ Chicago, Med Ctr, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA.
6) Ridker PM et al. Inflammation, aspirin and the risk of cadiovascular disease in apparently healthy men. NEJM 1997(April 3);336(14):973-979.
7) Gupta S et al. Circulation 1997;96:404-407. 8) Lancet August 9, 1997. Conclusions An increased anti-Cp antibody titre may be a predictor for further adverse cardiovascular events in post-MI patients. Taking a short course of azithromycin may lower this risk, possibly by acting against Cp. S Gupta, EW Leatham, D Carrington, MA Mendall, JC Kaski, AJ Camm. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation 96: 2 (JUL 15 1997):404-407.
8) M Maass, E Krause, PM Engel, S Kruger. Endovascular presence of Chlamydia pneumoniae in patients with hemodynamically effective carotid artery stenosis. Angiology 48: 8 (AUG 1997):699-706.
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13) S Mazzoli, N Tofani, A Fantini, F Semplici, F Bandini, A Salvi, R Vergassola. Chlamydia pneumoniae antibody response in patients with acute myocardial infarction and their follow-up. American Heart Journal 135: 1 (JAN 1998):15-20.
14) JB Muhlestein, JL Anderson, EH Hammond, LP Zhao, S Trehan, EP Schwobe, JF Carlquist. Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 97: 7 (FEB 24 1998):633-636.
15) PJ Cook, D Honeybourne, GYH Lip, DG Beevers, R Wise, P Davies. Chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia: The West Birmingham Stroke Project. Stroke 29: 2 (FEB 1998):404-410.
16) PJ Cook, GYH Lip, P Davies, DG Beevers, R Wise, D Honeybourne. Chlamydia pneumoniae antibodies in severe essential hypertension. Hypertension 31: 2 (FEB 1998):589-594.
17) H Toss, J Gnarpe, H Gnarpe, A Siegbahn, B Lindahl, L Wallentin. Increased fibrinogen levels are associated with persistent Chlamydia pneumoniae infection in unstable coronary artery disease. European Heart Journal 19: 4 (APR 1998):570-577.
18) TC Quinn. Does Chlamydia pneumoniae cause coronary heart disease? Current Opinion in Infectious Diseases 11: 3 (1998):301-307.
19) PM Ridker, RJ Glynn, CH Hennekens. C-Reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation 97:
20 (MAY 26 1998):2007-2011. 20) M Maass. Persistence of Chlamydia pneumoniae in human atherosclerotic plaques material - Evidence and consequences. Herz 23: 3 (MAY 1998):178-184.
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24) JL Anderson, JF Carlquist, JB Muhlestein, BD Horne, SP Elmer. Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction. Journal of the American College of Cardiology 32: 1(JUL 1998):35-41.
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26) AS Gabriel, H Gnarpe, J Gnarpe, H Hallander, O Nyquist, A Martinsson. The prevalence of chronic Chlamydia pneumoniae infection as detected by polymerase chain reaction in pharyngeal samples from patients with ischaemic heart disease. European Heart Journal 19: 9 (SEP 1998):1321-1327. 2
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