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Kidney Stones and Nanobacteria

It appears that infections may be a major cause of kidney stones. In 1996, researchers from Turkey (1) and Finland (2) reported that newly discovered bacteria called nanobacteria, cause kidney stones. Researchers in Formosa have reported finding a common intestinal bacteria called proteus and another often sexually transmitted bacteria called ureaplasma in kidney stones (3).

Doctors used to tell their patients with kidney stones to reduce their intake of calcium, but recent research shows that restricting calcium causes stone formers to increase their chances of getting kidney stones (4,5) and osteoporosis (6). Doctors failed to find infections in kidney stones before because nanobacteria are so small that they cannot be seen by conventional microscopes, but can be seen through the super powerful electron microscope. They do not stain with conventional bacterial stains, they do not grow in conventional laboratory agar and they grow very slowly on special media. Nanobacteria cause calcium, phosphorus and other minerals to form carbonate apatite as a shell around them, that is a major component of kidney stones. Antibodies that bind to nanobacteria were found in all 30 stones tested. Tetracycline antibiotics accumulate in the calcium shell, and have been shown to kill nanobacteria. There are no studies to test whether daily intake of doxycycline could prevent kidney stones, but these tests should be started soon. Treatment of kidney stones with antibiotics is controversial and not accepted by most doctors. Discuss this with your doctor or any new findings on avoiding kidney stones.
Dietary Calcium and Kidney Stones

1) A Yuce, M Yucesoy, K Yucesoy, T Canda, M Fadiloglu, A Gure, N Yulug. Ureaplasma urealyticum induced urinary tract stones in rats. Urological Research 24: 6 (DEC 1996):345-348.

2) Kajander EO et al. Proceedings of the National Academy of Sciences. July 7, 1998.

3) HS Huang, J Chen, LJ Teng, MK Lai. Use of polymerase chain reaction to detect Proteus mirabilis and Ureaplasma urealyticum in urinary calculi. Journal of the Formosan Medical Association, 1999, Vol 98, Iss 12, pp 844-850.

4) M Liebman, WW Chai. Effect of dietary calcium on urinary oxalate excretion after oxalate loads. American Journal of Clinical Nutrition. 65: 5(MAY 1997):1453-1459.

5) GC Curhan, WC Willett, FE Speizer,D Spiegelman, MJ Stampfer. Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women. Annals of Internal Medicine. 126: 7 (APR 1 1997):497.

6) A Trinchieri, R Nespoli, F Ostini, F Rovera, G Zanetti, E Pisani. A study of dietary calcium and other nutrients in idiopathic renal calcium stone formers with low bone mineral content. Journal of Urology 159: 3 (MAR 1998):654-657. Restricting calcium causes osteoporosis.

Checked 6/29/14

January 1st, 2015
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About the Author: Gabe Mirkin, MD

Sports medicine doctor, fitness guru and long-time radio host Gabe Mirkin, M.D., brings you news and tips for your healthful lifestyle. A practicing physician for more than 50 years and a radio talk show host for 25 years, Dr. Mirkin is a graduate of Harvard University and Baylor University College of Medicine. He is board-certified in four specialties: Sports Medicine, Allergy and Immunology, Pediatrics and Pediatric Immunology. The Dr. Mirkin Show, his call-in show on fitness and health, was syndicated in more than 120 cities. Read More
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