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Preventng Dementia

More than one in 10 North Americans wil suffer from dementia. Today there is no effective treatment for dementia, but in the last month, several reports have shown that dementia may be delayed and prevented by:
• training your brain with special exercises,
• exercising your muscles regularly,
• avoiding smoking and smokers,
• following a healthful high-plant diet, and
• preventing and treating everything that damages arteries, which also can damage your brain: heart disease, strokes, diabetes and high blood pressure.

Exercising Your Brain
At the International Conference of the Alzheimer’s Association in Toronto on July 24, 2016, data was presented showing that older adults, averaging 73 years of age, who practiced increasing the speed at which they processed visual information for 10 years, reduced their chances of suffering dementia by 33 percent compared to those who received no training. This is supported by several previous studies showing that people who work at jobs or regular activities requiring complex thinking are at reduced likelihood to develop dementia.

Exercising Your Muscles
UCLA researchers followed the physical activity and did brain MRIs of 3700 aging men and women, over 60 years of age, for more than 10 years and found that the most active people had larger hippocampi, the part of the brain that controls short-term memory formation. The greatest benefit from exercise was seen in the people who were 75 or older (J of Geron Ser A: Biol Sci and Med Sci, August 2016).

Canadian researchers analyzed brain scans of 330 healthy adults, ages 19 to 79, and showed that those who walked up and down stairs regularly had younger and larger brains compared to those who did not use stairs (Neurobiology of Aging, April 2016;40:138–144). They estimated that for every flight of stairs per day a person reduces brain age by half a year. Walking up stairs burns two to three times as many calories as walking on level surfaces.

Overwhelming data show that regular exercise improves memory. Exercising muscles produce, and release into the bloodstream, a substance called cathepsin B (CTSB) that has been shown to increase memory and grow nerves in mice, monkeys and humans (Cell Metabolism, June 12, 2016). Many previous studies show that the higher the blood level of CTSB, the greater the improvement in fitness level and memory. Researchers showed that after just one week of exercise, a normal mouse's memory improved dramatically. However mice who were genetically engineered to be unable to produce CTSB gained no memory improvement from exercise. Other exciting new studies are proceeding right now to find out if CTSB given to people will help to prevent or treat Alzheimer’s amyloid plaques.

A Healthful Plant-Based Diet
The high-plant MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) has been shown to reduce a person’s risk for developing Alzheimer’s disease by more than 50 percent (Alzheimer’s & Dementia, March 2015), as well as helping to prevent heart attacks. The MIND diet, based on the DASH diet and the traditional Mediterranean diets, includes lots of foods from plants (leafy greens and other vegetables, nuts, berries and other fruits, beans, whole grains). It can include fish, poultry, olive oil and wine but avoids red meats, butter, stick margarine, cheese, fried foods, pastries and sweets.

Earlier studies show that limiting sugar and controlling weight help to prevent dementia as well as diabetes and heart disease (N Eng J Med, Aug 8, 2013;369:540-548). Forty percent of North Americans will suffer from high blood sugar levels that are part of metabolic syndrome, pre-diabetes or diabetes, which all increase risk for dementia. Vegans live longer than those who eat meat and other animal products; each three per cent increase in calories from plant protein was found to reduce risk of death by 10 per cent (JAMA Int Med, August 1, 2016).

Avoiding Smoking
Smoking causes inflammation and oxidative stress. People who smoke develop dementia an average of 23 years earlier than nonsmokers, from damaged blood vessels (J. Cell. Mol. Med, 2008;12(6B):2762-2771) and nerves (Dement Geriatric Cogn Disord, 2010;30(3):277-84).

My Recommendations
These recent studies show that you may be able to delay and perhaps prevent Alzheimer's disease and other forms of dementia by:
• Exercising your brain
• Exercising your muscles
• Eating a healthful plant-based diet and restricting red meat (meat from mammals), sugar-added foods, sugared drinks including fruit juices, and fried foods
• avoiding tobacco and alcohol
• controlling high blood pressure, high cholesterol and high blood sugar.

Any activity that challenges your brain counts as "exercise", and the more complex the activity and the more often you do it, the better. It can be as simple as counting steps when you walk, reading, writing, drawing or painting, doing puzzles and playing games that require thinking. Limit the amount of time you spend in passive brain activities such as watching television.

I will watch for future research on cathepsin B (CTSB) to see if this chemical produced by exercising muscles is effective as a medication for preventing or treating dementia. 

August 7th, 2016
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About the Author: Gabe Mirkin, MD

Sports medicine doctor, fitness guru and long-time radio host Gabe Mirkin, M.D., brings you news and tips for your healthful lifestyle. A practicing physician for more than 50 years and a radio talk show host for 25 years, Dr. Mirkin is a graduate of Harvard University and Baylor University College of Medicine. He is board-certified in four specialties: Sports Medicine, Allergy and Immunology, Pediatrics and Pediatric Immunology. The Dr. Mirkin Show, his call-in show on fitness and health, was syndicated in more than 120 cities. Read More
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