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What do you think when you hear that an over-the-counter pill helps to treat depression, arthritis and liver disease and is completely safe? It's called SAMe (pronounced "Sammy") and so far, few side effects have been reported from taking it.

All protein in your body is made from building blocks called amino acids. Of the 21 in your body, 9 are essential and must be obtained from the food that you eat. The other 12 are called non-essential because your body can make them from the essential 9. In your body, the essential amino acid, methionine, forms the non-essential amino acid, cysteine. But before it does this, methionine is converted to SAMe which helps form cartilage to alleviate pain in arthritis, raises brain levels of serotonin to treat depression, and helps the liver repair itself by some unknown mechanism. If you have enough of the vitamins folic acid, pyridoxine and B12, SAMe is recycled back to methionine or is converted to glutathione that helps protect your body from injury. If you lack B12, pyridoxine or folic acid, SAMe is converted to homocysteine which can cause birth defects, heart attacks, strokes and depression.

With all the good news about the function of SAMe in your body, there is no scientific evidence that taking SAMe as a supplement has any benefit. It is far more important that you have enough vitamins B12, pyridoxine and folic acid to convert the SAMe made in your own body to the healthful glutathione. If you do not have enough of these three vitamins, SAMe is converted to the harmful homocysteine. Scientists do not know all the side effects of SAMe supplements and they have no idea whether you will be harmed years later. The supplement industry is not regulated so the marketers of SAMe are not required to answer these questions. You don't even have any way to know if the pills actually contain any SAMe.

Checked 7/10/06

May 12th, 2013
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About the Author: Gabe Mirkin, MD

Sports medicine doctor, fitness guru and long-time radio host Gabe Mirkin, M.D., brings you news and tips for your healthful lifestyle. A practicing physician for more than 50 years and a radio talk show host for 25 years, Dr. Mirkin is a graduate of Harvard University and Baylor University College of Medicine. He is board-certified in four specialties: Sports Medicine, Allergy and Immunology, Pediatrics and Pediatric Immunology. The Dr. Mirkin Show, his call-in show on fitness and health, was syndicated in more than 120 cities. Read More
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