A study from Columbia Medical School shows that many postmenopausal women who take estrogen replacement have reduced sexual interest and desire, and giving these women the male hormone, testosterone, significantly increases their interest and desire.

Masculinizing hormones are far more effective than feminizing hormones in increasing a woman's interest and desire in lovemaking. The brains of normal women produce hormones called FSH and LH that stimulate the ovaries to produce both male and female hormones. When male and female hormones rise too high, they prevent the brain from producing the hormones that stimulate the ovaries. So giving postmenopausal women the female hormone, estrogen, can stop their brains from making FSH which stimulates the ovaries to make masculinizing hormones. Giving these women both estrogen and testosterone pills markedly elevated their blood levels of masculinizing hormones, and increased their interest in making love.

0.625 mg of esterified estrogens and 1.25 mg of methyltestosterone testosterone and suppressed SHBG. Scores measuring sexual interest or desire and frequency of desire increased from baseline with combination treatment and were significantly greater than those achieved with esterified estrogens alone. Title Comparative effects of oral esterified estrogens with and without methyllestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertility and Sterility, 2003, Vol 79, Iss 6, pp 1341-1352. RA Lobo, RC Rosen, HM Yang, B Block, RG VanderHoop. Lobo RA, Columbia Univ Coll Phys & Surg, Dept Obstet & Gynecol, 622 W 168th St, New York,NY 10032 USA

Checked 9/5/05

Get our newsletter