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Aspirin to Prevent Colon Cancer?

People who take aspirin are at reduced risk for colon cancer, unless they are among the four percent of North Americans who have a genetic susceptibility for colon cancer (JAMA, March 17, 2015;313(11):1133-1142). Colon cancer is the second leading cause of cancer death in the United States (after lung cancer), with 1,162,426 people living with colon and rectum cancer today.

If you have polyps in your colon or a strong family history of colon cancer, your doctor may recommend one adult aspirin every other day based on this study and others that show possible benefit. This study analyzed genetic and lifestyle data from 10 large epidemiologic studies of 17,000 people and found that aspirin appears to reduce risk for colon and rectal cancer by 30 percent. However, aspirin may increase risk in the four percent of North Americans who have a genetic risk for colon cancer. Aspirin blocks certain prostaglandins, and some metabolites of prostaglandins turn on your immunity to cause inflammation which can cause and spread cancer. Colon cancer cells make more prostaglandins than surrounding tissue and blocking certain prostaglandins prevents colon cancer. Until genetic testing for colon cancer risk is available, I would not recommend taking aspirin.

Checked 9/2/15

March 20th, 2015
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About the Author: Gabe Mirkin, MD

Sports medicine doctor, fitness guru and long-time radio host Gabe Mirkin, M.D., brings you news and tips for your healthful lifestyle. A practicing physician for more than 50 years and a radio talk show host for 25 years, Dr. Mirkin is a graduate of Harvard University and Baylor University College of Medicine. He is board-certified in four specialties: Sports Medicine, Allergy and Immunology, Pediatrics and Pediatric Immunology. The Dr. Mirkin Show, his call-in show on fitness and health, was syndicated in more than 120 cities. Read More
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